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G.HolmesC.et al (2004)

Substrate-induced conformational dynamics of the dopamine transporter

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

We detail how these -glutamylcyclotransferases degrade GSH, thereby modulating cellular redox balance and integrating diverse stress signaling pathways

In parallel, several research groups have reported that astaxanthin may contribute to the maintenance of skin wrinkles and elasticity since its action in the dermis, where the impact of singlet oxygen seems to be strongest, is expected to protect the matrix that maintains the elasticity of the epidermis, such as collagen and elastin, from 1 O 2

By using mice deficient in glutamate-cysteine ligase (GCL) in keratinocytes, the authors found that GSH deficiency results in more DNA damage and cell death, suggesting a crucial role for the antioxidant capacity in skin integrity maintenance [93]