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Furthermore, Doll et al

Onset timings are typical ranges reported in supervised protocols, not guarantees, and vary considerably by individual

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doi: 10.1002/rcm.4077

In response to cystine deprivation, p53-mediated p21 expression reduces both of cellular glutathione and ROS levels leading to the inhibition of ferroptosis [47]
Under the high-iron environment, the levels of glutathione, catalase, and manganese superoxide dismutase are significantly elevated in astrocytes to counteract oxidative stress (Iwata-Ichikawa et al., 1999