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Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis

In another study, vitamin B12 at concentrations above 100 nM is shown to increased Erk1/2 and Akt activities during the methylation cycle and subsequently facilitated neuronal growth 16

This interaction was mapped at the hydrophobic domain of G0S2 and the patatin-like domain of PNPLA2, whereby overexpression of G0S2 diminished adipocyte lipolysis, and deletion increased both basal and stimulated lipolysis (52)

PMID 23870976

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Better metabolic efficiency: Some patients report favorable body composition shifts over multiple cycles, especially when combined with consistent training and nutrition