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The inability to consume pyruvate alternatively results in its reduction to lactate, causing lactic acidosis (Rodrigues et al., 2018

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doi: 10.1542/peds.2012-0253

The bottom line The FDA has scheduled PCAC hearings (July 2324, 2026 and a second meeting before the end of February 2027) to evaluate whether certain peptides should be added to the 503A bulks list, but formal rulemaking is still required before routine legal compounding from bulk substances is permitted

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Acute and chronic manifestations