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Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy

The clinical need must be considered in addition to any potential adverse outcomes for the infant

1:502:00 pm CDT 1966-LB Efficacy and Safety of Semaglutide 7.2 mg in ObesitySTEP UP Trial Sunday, June 22

10.3831/KPI.2020.23.008 263 ShiP.XieS.YangJ.ZhangY.HanS.SuS.et al (2022)

In 2003, a Cochrane review of three RCTs on cognitive function in patients with AD or other forms of cognitive impairment also found no evidence of benefits of B12 on cognitive function compared with placebo