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doi: 10.1096/fj.07-8290com

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

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The hypothesis proposes cells at risk of being driven into the IDO metabolic trap include antigen-presenting cells, serotonergic neurons in the midbrain raphe nuclei, serotonin-producing enterochromaffin cells in the intestinal mucosa, and melatonin-producing pinealocytes

Our study confirmed that SFN can be effective against cutaneous inflammation in an IMQ-induced psoriatic mouse model, consistent with previous findings of its therapeutic effects in chronic inflammatory diseases such as inflammatory bowel disease, respiratory diseases, and rheumatoid arthritis [35]