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Piperine, a major component of black pepper, inhibits UDP-glucuronosyltransferase and hepatic arylhydrocarbon hydroxylase, thereby reducing the first-pass metabolism of compounds such as curcumin

Collaborations & Alliances 10.1.1.4

STEP 5 shows that the changes in these parameters were sustained through 104 weeks treatment

10.1016/j.bbcan.2012.06.003 10.1016/j.bbcan.2012.06.003 [DOI] [PMC free article] [PubMed] [Google Scholar] Duong C, Seow HJ, Bozinovski S (2010) Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice
Some research suggests glutathione could influence thyroid function, so getting professional guidance makes sense before starting treatment

Several antidepressants, including paroxetine, sertraline, venlafaxine and citalopram/escitalopram, have been reported as P-gp substrates to varying degrees, indicating that interindividual differences in ABCB1 function may modulate both efficacy and tolerability of SSRI/SNRI therapy (O'Brien et al., 2012a
