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The problem of resistance is relevant not only for conventional chemotherapeutic drugs but also for targeted drugs, as exemplified by resistance development in CML upon treatment with the novel drug imatinib (Gleevec) that inhibits the BCR-ABL kinase (37)

doi: 10.1016/j.ophtha.2011.03.016

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In addition, combined with lenalidomide or melphalan, treatment with GSK-3 inhibitors induced MICA expression and increased NK cell-mediated tumor killing by promoting NKG2D recognition in NK cells

EGCG or Zn alone also exerted partial protective effects, with EGCG predominantly associated with reduced p-p38 activation and Zn mainly associated with enhanced expression of -catenin and E-cadherin, suggesting that EGCG-Zn may integrate functional features of both components

Evaluation of the effects of L-carnitine on renal histopathological changes The kidneys of the control, sham and L-ca 200 groups were completely normal and healthy in the terms of histo-architecture (Fig