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Specifically, MOTS-c promoted the differentiation of CD4 + CD25 + FOXP3 + regulatory T cells (Tregs), which exhibited low glycolytic activity and showed therapeutic potential in type 1 diabetes (T1D) and other autoimmune diseases, through direct inhibition of mTOR complex 1 (mTORC1) signaling in T cells [86]

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[DOI] [PubMed] [Google Scholar] 367.Wang MS, Boddapati S, Emadi S, and Sierks MR

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However, drug efflux can be reduced through the use of BCRP inhibitors, such as gefitinib, a TKI that blocks BCRP transporter function, restoring drug sensitivity (263)
