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escalation stops once the effect target is met and tolerated

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doi: 10.1186/s12882-019-1425-8 41 BarzilayJIFitzpatrickALLuchsingerJYasarSBernickCJennyNSet al

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The tumor bed was defined as the sum of 1) residual viable tumor (RVT), 2) necrosis, and 3) regression bed characterized by the presence of dense tumor-infiltrating lymphocytes (TIL) infiltrates, tertiary lymphoid structure (TLS), features of cell death (keratinous debris and giant cells), and tissue repair (neovascularization, fibrosis)
