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Las dosis altas pueden causar dolores de cabeza temporales debido al aumento del recambio de NAD+ y de la actividad mitocondrial

Inhibiteurs de la pompe protons (IPP) : comme lomprazole, ces mdicaments contre les reflux diminuent lacidit gastrique, essentielle la libration de la B12 des aliments

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Bitots spot is a superficial, foamy or cheesy-looking lesion on the conjunctiva, typically appearing on the temporal (outer) side of the eye

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Additionally, because its synthetic, it may be less bioavailable (less easily absorbed) than naturally occurring forms