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The SARS-CoV-2 infection initiates complex human host-pathogen interactions and alters mitochondrial function with significant disruption of glycolysis/TCA cycle (Warburg effect), affecting several metabolic pathways of amino acid (AA), fatty acid (FA), nucleotide, and antioxidant synthesis 139,140

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If GSH synthesis is inhibited by either depletion of the incubation medium of GSH precursors or by the presence of the GCL inhibitor buthionine sulfoximine (BSO), the GSH content of cultured murine astrocytes declines with a halftime in the hour range (Arend et al

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