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Several studies have been conducted to identify targetable molecules from these signaling pathways that characterize various inhibitors or drug molecules (304, 305)

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The present findings were supported by previous studies which reported significant decrease in glutathione peroxidase, catalase and glutathione, and significant increase of MDA concentration [74] and AR activity [75] in type 1 diabetic patients respectively

A key mechanism of L-arginine depletion is upregulation of arginase, an enzyme that competes with eNOS for L-arginine and converts it into urea and L-ornithine

Neurobiol Dis 37(1):1325

Measurements Metabolomics measurements were performed at Metabolon, Inc (Morrisville, NC, USA)