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This work also was supported by Guangdong Province-Provincial Chinese Medicine construction special fund named Traditional Chinese Medicine Inheritance Studio construction project Guangdong Chinese Medicine Office Letter (2023) 108

10.1038/s41556-020-0461-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 288.Li, C

[1] The complete amino acid sequence of AOD-9604 is: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH, with a disulfide bond bridging the two cysteine residues at positions 6 and 13 to form a cyclic internal structure

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Safranal, a monoterpene aldehyde responsible for the characteristic smell of saffron, is an antioxidant that contributes to lowering oxidative stress in the neurons, inhibiting the production of pro-inflammatory cytokines and balancing the equilibrium between free radicals and antioxidants activity (Seyedinia et al., 2023)

a prophylactic dose dose contemplates a dose that may be slightly less than the normal minimum amount of a pharmaceutical drug that will treat a biological or medical event that is sought to be overcome in a tissue, a system, animal or human by a researcher, veterinarian, medical doctor or other clinician, and addresses the problem of minimizing the toxicity of many drugs while having at least some of the drug present in the mammalian system to reduce the time before effective treatment by a drug begins