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To maintain homeostasis, a reflex increase in tear secretion occurs to clear irritating eyedrops, which further reduces the ocular bioavailability of the drug
Clarifying the apicobasal localization of ZIP8, ZIP14, and ZNT10 and understanding their coordinated regulation under Mn deficiency or overload will be critical to delineate how Mn fluxes are maintained during metabolic or inflammatory stress

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Step-by-step Application Preparation: Ensure the skin is clean and dry

1993 Jun;22(6):399-419 51

Salsman et al., 2011
