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In the realm of biology, primary metabolites contribute to fundamental life cycle functions, such as growth, differentiation, and reproduction, while secondary metabolites serve various purposes, including signaling, protection, and activities unrelated to the life cycle (43)

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In addition, inflammation is closely associated with oxidative stress, which are able to trigger a series of transcription factors such as Nrf2, NF-B1, and pro-inflammatory cytokines such as TNF-, resulting in the differential expression of inflammatory cytokines, chemokines, and anti-inflammatory molecules [7, 53]