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Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition

doi: 10.1007/s00125-017-4390-4 11 JiaGHillMASowersJR

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They achieve this by regulating the differentiation of nave CD4 + T cells into specific T-helper (Th) subpopulations, such as Th1, Th2, and Th17, via the provision of co-stimulatory signals and the secretion of distinct cytokines (214, 269, 270)

[DOI] [PubMed] [Google Scholar] 67.An P., Wan S., Luo Y., Luo J., Zhang X., Zhou S., Xu T., He J., Mechanick J.I., Wu W.-C., et al

The overexpression of circulating IL-6 in mdx dystrophic mice (mdx/IL-6 mice) induced a significant exacerbation of the dystrophic phenotype with the long-term exhaustion of the satellite cell pool and the accumulation of FAPs [33]
