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One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress

doi: 10.2174/138920012803762765

Each signature was queried against the CMap using the algorithm described by Lamb et al .[13]
Bone health in patients with inflammatory bowel disease

Greenberger JS, Smith T, Schlesselman JJ, Epperly M

Hyperemesis gravidarum (HG), in contrast to normal NVP, is a rare and debilitating disorder of pregnancy, defined by the Windsor definition as nausea and vomiting, at least one of which is severe, starting in early pregnancy (before 16 weeks gestational age), and which causes an inability to eat and/or drink normally and strongly limits daily living activities
