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In a medically supervised, quality-controlled context with appropriate screening and protocol design, it is generally viewed as a reasonable regenerative strategy and is commonly reported as well tolerated

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As an adjuvant to iron chelation therapy (e.g., deferoxamine), vitamin C (in doses up to 200 mg/day for adults, 50 mg/day in children 500 mg/day PO of vitamin C in adults has lead to impairment of cardiac function

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