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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

All the same, some limitations exist

1 2 3 4 "Paracetamol: New vistas of an old drug"

The aberrant PI3K-Akt signaling in tumor cells is attributed to the platinum-resistant phenotype, and the combination of cisplatin and LY-294002 (a PI3K-Akt dual kinase inhibitor) was found to prevent 3D spheroid formation and sensitize cells to cisplatin [110]

Targeting astrocytes for treatment in amyotrophic lateral sclerosis

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