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Anaphylaxis is a life-threatening reaction that causes swelling and extremely low blood pressure

Note that our body is not very efficient at absorbing vitamin B12 from supplements, so it's better to stay on the safe side by aiming to consume well over the minimum recommended amount, rather than taking a little less or sticking to the RDI

Additionally, excessive alcohol consumption can impair liver function and gut health, reducing the bodys ability to efficiently absorb and store the vitamin

People with a known cobalt allergy, typically identified by reactions to metal jewelry or implants, may occasionally react to vitamin B12 supplements because cobalt is a structural component of all cobalamins

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Vitamin B5 can lead to eosinophilic pleuropericarditis and patients should be checked if they have a history of allergies to it