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Description
While mild inflammation is sometimes needed to fight infections, sustained oxidative stress may promote a wide variety of diseases and disorders

The most affected area is the centrilobular zone (zone III) due to the greater distribution and content of CYP450, and thus greater bioactivating capacity of hepatocytes in that region

10.1016/j.febslet.2013.09.031

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doi: 10.1155/2015/590987 12 RoeselMJSharmaNSSchroeterAMatsunagaTXiaoYZhouHet al

(306) Zhang, B