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Additionally, the RAS/BRAF/MEK/MAPK pathway along with the voltage-dependent anion channel (VDAC) was implicated in this process, contributing to oxidative stress and mitochondrial dysfunction [24]

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10.1002/hep.1840220312 Hepatology Summary Keywords mitochondria, lysosomes, acetaminophen APAP, mitophagy, lysosomal cholesterol accumulation Citation Moles A, Torres S, Baulies A, Garcia-Ruiz C and Fernandez-Checa JC (2018) MitochondrialLysosomal Axis in Acetaminophen Hepatotoxicity

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Tissue homogenates were subjected to centrifugation (20,000 x g, 30 min, 4 C) and supernatant collected as a TBS-soluble fraction and stored at 80 C until used

Significant visible change in abdominal fat