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In addition, emerging AI-driven frameworks for nanoparticle design and prediction are highlighted as tools that may accelerate optimization and therapeutic personalization

DeUgarte CM, Bartolucci AA, Azziz R

Paul Maguire, Bradley T

The kidneys cellular heterogeneity and complex architecture pose challenges for directly assessing the pharmacologic effects on kidney oxygenation and hypoxia-responsive pathways in vivo, such as treatment with SGLT2 inhibitors (SGLT2i), presumed to impact kidney oxygenation

Its use is limited to experimental and analytical investigation only and does not extend to therapeutic, diagnostic, or clinical applications

Permeation Studies Even though permeability of oral mucosa is 4-1000 times greater than that of skin, permeation studies should be carried out