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Mechanistically, the accumulation of intracellular copper ions induced by the downregulation of COMMD10 can inhibit the ubiquitin-mediated degradation of HIF-1, subsequently increasing the transcription and translation of ceruloplasmin, which forms a positive feedback regulation loop of HIF-1/CP to inhibit ferroptosis, thereby promoting the radiotherapy resistance of liver cancer cells [187]
Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model
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Gastroenterology 2008
Inhibition of frataxin extends C
