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Cleavage of the C-terminal NCI domain of type XV collagen results in the production of restin, a molecule shown to possess antiangiogenic properties in vitro by inhibiting bFGF-induced EC migration and in a xenograft carcinoma model in vivo 107,108

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Both drug classes inhibit fibrotic progression and pulmonary inflammation by targeting key pathwaysNF-B signaling and NLRP3 inflammasome activationthereby disrupting pro-inflammatory cytokine cascades (Shakour et al., 2024

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

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