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Free Radic Biol Med 216:6077

Vgontzas AN, Pejovic S, Zoumakis E, Lin HM, Bixler EO, Basta M et al (2007)
Most drug molecules enter the brain by paracellular or transcellular passive diffusion, though passive diffusion is limited in the brain compared to other tissues
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Recombineering: a homologous recombination-based method of genetic engineering
