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10.1016/j.jcmgh.2021.02.007 187

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People with Severe Rosacea or Broken Skin: While GHK-Cu reduces inflammation in theory, applying a copper complex to severely compromised or acutely inflamed skin can sometimes trigger a flare-up

This excitotoxic cascade is one of the primary mechanisms by which the ischemic penumbra is recruited into the infarct core
