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The mechanisms by which Tbx1 mutation affects brain development and brain function are unknown, but they are non-cell-autonomous mechanisms (37) because in the mouse brain, Tbx1 expression is limited to brain vessels, and it is not expressed in neurons or other brain cell types (2, 38) ( Moreover, not all brain ECs express Tbx1

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Cell nucleus morphology (oval/elongated) and vascularity were significantly higher in the PF group compared to the other groups in the fourtth-week sections ( p = 0.003)

doi: 10.1021/jm5006463

Limitations include: Enzymatic and chemical degradation Poor membrane permeability Comparatively large molecular size When a peptide like epithalon is unmodified, bioavailability may be less than 1%