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Acknowledgements We thank Abdel Belaidi for comments on the manuscript, Nicholas Stroustrup and Walter Fontana for providing their raw data to enable validation of our temporal scaling analysis and acknowledge the Australian Synchrotron

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Lyu et al., 2021), among which IL-1 plays a central role in promoting matrix degradation and pain generation (Phillips et al., 2015)

As indicated above the elevated NADH resulting from the metabolism of ethanol results in the impairment of hepatic gluconeogenesis from lactate, alanine (and other amino acids), and glycerol