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In fact, transplanting senescent cells into mice knee joint has been found to induce an osteoarthritis-like change (Xu et al., 2017)

This suggests that intranasally or orally delivered (nose-to-brain) formulations of such complexes may be suitable for preventing or treating neurodegenerative diseases

In early trials, stem cells were transplanted into patients with ALS with the goal of generating new motor neurons

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showed that mitochondria-targeted honokiol (Mito-HNK) combined with lonidamine (Mito-LND) disrupts oxidative phosphorylation, leading to an 83% reduction in tumor burden in murine models (Zhang et al
