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Since tirzepatide already activates the GLP-1 receptor along with the GIP receptor, combining it with semaglutide could overstimulate these pathways
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[DOI] [PubMed] [Google Scholar] [34].Makino Y, Yoshikawa N, Okamoto K, Hirota K, Yodoi J, Makino I, et al
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10.1212/01.WNL.0000068030.26992.25 136
