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Regulated ATP release from astrocytes through lysosome exocytosis

For instance, TNBC (MDAMB231) cells produced cathepsin S to proteolyze the junctional adhesion molecule JAM-B [124], and secreted miRNA-181c-enriched extracellular vesicles to down-regulate phosphorylated cofilin for interrupted actin dynamics [125], which ultimately led to BBB breakdown

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