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analyzed the effects of Isatuximab, the second anti-CD38 reagent approved by the FDA, on NK cells, which express CD16, a low affinity FcR ( Overall, these results suggest that some of the therapeutic actions of the antibody are mediated by direct signaling through the CD38 molecule, without the effects driven by FcRs, at least in the NK cells tested in vitro

Nevertheless, it has become a widely used research tool in metabolic diseases and muscle health, laying a critical foundation for mechanistic and therapeutic exploration in related fields

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GeroScience 45 , 2943 (2023)