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Additionally, neurotoxins induce nuclear fragmentation, endoplasmic reticulum (ER) stress and unfolded protein response in catecholaminergic cells, which are associated with changes in proteasomal and chaperone activities, similar to those observed in PD [45,55]

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28 As part of these changes, manufacturers will now be required to report more detailed information on pharmaceutical supply disruptions to FDA, including any events that may have led to the shortage, its likely extent and duration, and the expected impact

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Mol Metab 2020;34:16-26.ArticlePubMedPMC 72

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doi: 10.1016/j.pbi.2020.10.007 97 VaddeB

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Prostate 34 , 283291 (1998)

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J.LikhiteS.McelroyS.RenuschS.et al

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