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Thus, impaired recognition of EBV-infected or latent EBV-infected cells by CD4 T cells in individuals with the HLA-DR15 allele may result in uncontrolled expansion of CD8 T cells and increased production of anti-EBNA-1 antibodies, contributing to infectious mononucleosis and the development of multiple sclerosis (122, 299, 300)

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Glucose-6-phosphate dehydrogenase (G6PD) is a key gene in the context of GMPGs and plays a critical role in maintaining cellular redox balance and protecting cells from oxidative damage [12]

whereas the enzymes that shed glycocalyx components include the neuraminidases, heparanase, hyaluronidases, MMPs, and a disintegrin and metalloproteinases (ADAMs) (1, 127, 168, 199, 201, 290)