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(3) Targeted Delivery and Site-Specific Activation: Ensuring brain delivery while controlling peripheral exposure, favoring targeted delivery systems and site/environment-activated prodrugs (e.g., ROS-responsive or target enzyme-activated) to confine activity to the pathological microenvironment, thus balancing brain access and safety [127, 129, 135, 136]

Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes

Importantly, several patients demonstrated significant durations of disease stability following treatment, suggesting DEXs ability to activate immune responses against tumors

Viral delivery of a microRNA to Gba to the mouse central nervous system models neuronopathic Gaucher disease

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