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Phase 1 safety trials must determine maximum tolerated dose and identify adverse effects

But some PMR symptoms can overlap with fibro, especially the widespread achiness and interrupted sleep

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Many researchers also track body composition changes through DEXA scans or bioimpedance measurements at regular intervals

7 An autopsy study also found that iron levels were significantly elevated (two to three-fold) in the extrapyramidal brain regions (SN, putamen, and caudate nucleus) compared to the cerebral cortex and cerebellum of PD patients