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In a recent study, MOTS-c treatment significantly alleviated hyperglycemia and improved insulin sensitivity in gestational diabetic mice, and reduced mortality in offspring [76]

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Most clinical studies assess outcomes at 24 weeks, with continued improvement typically observed through 12 to 24 months of use

This was observed after a frataxin minigene (made up of FXN exon1, CMV promoter, part of intron 1 and the entire exon 2) transfected into COS7 cells and HeLa cells showed splicing deficiency when the GAA dominant strand was transcribed ( 4 Oxidative stress in FRDA Oxidative stress has been implicated in the progression of neurodegenerative disorders such as Alzheimers Disease (AD), Parkinsons Disease (PD), and Huntingtons Disease (HD), as well as FRDA (Tamarit et al., 2016)

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