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Similarly, ROS-induced ER stress triggers the unfolded protein response (UPR), which leads to further cell apoptosis and the immune system targeting melanocytes 56

Caloric restriction, intermittent fasting, and omega-3 fatty acid intake have demonstrated reductions in biological age acceleration, particularly at CpG sites associated with inflammation and metabolic regulation [73]

Diabetes Care 21 , 278282 (1998)

Evans, L., Mohamed, B

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The liver histology of these patients had dense lymphoplasmacytic portal tract infiltrate, periportal hepatitis, and bridging collapse, similar to AIH