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Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing

Notably, elevated levels of pro-inflammatory cytokines, such as interleukin-1beta(IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and interferon-gamma (IFN-), have been consistently observed in patients with ME/CFS [33, 34]

Fibroblast activation and extracellular matrix deposition are crucial for wound closure and tissue integrity restoration, as well as to the formation of fibrotic scar formation in the adult mammalian CNS 164,167

Images were quantified via Fiji/ImageJ for mean pixel intensity

In humans, the posterior hippocampal neural projections to the PFC are involved in memory formation, whereas the anterior hippocampal neural circuit with limbic-prefrontal circuits and the amygdala are involved in anxiety

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