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Research involving reproductive-aged men demonstrated that urinary levels of phthalate monoesters and oxidative metabolites were significantly associated with increased sperm DNA damage, indicating direct genotoxic effects of these ubiquitous chemicals ( 4.1.1.3 Hormonal regulation and EED impact The fundamental role of androgens in spermatogenesis regulation provides a critical framework for understanding EED reproductive toxicity

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Although several in vivo and ex vivo studies have shown that NAC plays important biological actions that can potentially support its putative therapeutic roles, its effectiveness in clinical studies in addressing different pathological conditions still has conflicting results [4,9]

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