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Previous study have established that advanced maternal age have altered expression of genes involved in mitochondrial metabolic pathways in granulosa and cumulus cells compared with young 38,39

Apo E is crucial for this process and mutations in Apo E (for example homozygosity for the Apo E2 isoform) can result in decreased chylomicron clearance and elevations in plasma cholesterol and triglyceride levels (familial dysbetalipoproteinemia) (30)
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doi: 10.1016/j.cmet.2018.05.003

Are L-carnitine injections more effective than oral supplements
10.1146/annurev-physiol-020518-114310 83