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For example, dietary vitamin C supplementation was shown to relieve oxidative stress in STZ-induced diabetic aged rats by minimizing peroxidation levels and enhancing glutathione peroxidase activity in the lens [97]

Furthermore, when p53 was inhibited, JNK phosphorylation was enhanced to induce more severe liver injury in the APAP model

Cholic acid (CA) and chenodeoxycholic acid (CDCA) are primary BAs directly synthesized from cholesterol

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(33, 34) Acetaminophen is also toxic to the liver and kidneys