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Remarkably, the vast majority of the molecules identified in this screen have been described to form complexes with metal ions or to either inhibit NF-B and/or the Akt/GSK3 pathway (Table 1)

Developed through structure-guided design, 5-Amino-1MQ represents a novel therapeutic approach to metabolic regulation that works by modulating the NAD+ salvage pathway and cellular energy metabolism

E., Imperato-McGinley, J., Gautier, T