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Preclinical Findings (Animal & Cellular) Adipose NNMT inhibition increases energy expenditure and reduces fat mass

5-Amino-1MQ Regulatory Status As of June 2026, 5-Amino-1MQ is not FDA-approved for any human use

2004 Apr;5(4):43640

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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)