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The long latent period between the injection of a potential carcinogen and the appearance of a tumor makes it impossible to measure accurately the risk in man

These include how the patient is doing, any health problems, and the testing method

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Some patients report feeling less energetic during the initial months of treatment, with gradual improvement as weight stabilizes and metabolic adaptation occurs

Any clinical use should be undertaken with an honest acknowledgment of what the evidence does and does not support

In such cases, a refusal might be based on a misunderstanding of the condition and the patients needs