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doi: 10.1038/nrm2866 72 SinghRChandrashekharappaSBodduluriSRBabyBVHegdeBKotlaNGet al

Lions mane has growing interest and some RCT evidence, but its still early and not definitive

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However, theres a limitation

Small-molecule inhibitors of copper chaperone proteins The clinical use of copper ion chelators often leads to low copper ion concentrations, resulting in serious toxic side effects that disrupt other normal physiologic processes that require copper ions
