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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

Extreme sensitivity reactions such as rash, trouble breathing, swelling of the mouth, face, or throat should be reported to your prescriber immediately

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While cobalamin overdose is unheard of because it is non-toxic and water-soluble, cobalamin deficiency can happen due to a number of reasons, including certain diseases and genetic defects.

Adequate levels support normal energy metabolism, which may help reduce fatigue related to deficiency