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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Wu H., Wei M., Li N., Lu Q., Shrestha S.M., Tan J., Zhang Z., Wu G., Shi R

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